Analysis of mortality and risk of death in HCV- and HCV/HIV-infected patients with extrahepatic manifestations

The aim of the study was to analyze mortality patients infected with hepatitis C virus (HCV) and co-infected human immunodeficiency (HIV) extrahepatic manifestations associated cryoglobulinemia, assess dependence risk fatal outcome on such predictors as presence HIV infection, cirrhotic liver transformation, antiviral therapy (AVT) chronic C, cryoglobulin levels. Materials Methods. prospective included 125 HCV (n=92) HCV/HIV infection (n=33) who had (arthralgia and/or skin hemorrhagic rashes polyneuropathy or Raynaud’s syndrome xerophthalmia and/ kidney disease), well cryoglobulins. Results. 19 out (15% (95% CI 10-23%)) died in follow-up period from 1 170 months (median 57 months), among which 12 people did not receive AVT for during 7 underwent observation period. Unadjusted treated 9% 5–18%) (n=7/77), those it 25% 15–39%) (n=12/48), χ 2 =5,806, p=0,016. Cox regression analysis showed that an increase death is transformation by 5,3 times absence 3,7 times. main causes 69% cases were pathology, 26% complications cirrhosis (bleeding progressive encephalopathy), one case (5%) cause remained unknown. Conclusions. Мortality complicated development cryoglobulinemia higher than AVT. Cirrhotic significantly affect death. Patients die mainly pathology.